Of the total of 45 presidents of the United States eight have died in office. Four assassinations and four from natural causes as shown below.
| President | Death Date | Cause of Death | Location of Death |
|---|---|---|---|
| William Henry Harrison | April 4, 1841 | pneumonia or enteric fever | White House, Washington, DC |
| Zachary Taylor | July 9, 1850 | gastroenteritis | White House, Washington, DC |
| Abraham Lincoln | April 15, 1865 | assassination | Petersen House, Washington, DC |
| James Garfield | September 19, 1881 | assassination | Francklyn Cottage, Long Branch, New Jersey |
| William McKinley | September 14, 1901 | assassination | Milburn House, Buffalo, New York |
| Warren Harding | August 2, 1923 | heart attack | Palace Hotel, San Francisco, California |
| Franklin D. Roosevelt | April 12, 1945 | cerebral hemorrhage | Little White House, Warm Springs, Georgia |
| John F. Kennedy | November 22, 1963 | assassination | Dealey Plaza, Dallas, Texas |